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The antibody that normalizes tumor vessels

An important parcel must be delivered to the correct place. It is so important that it can be a question of life or death. However, uneven streets and missing railings risk to bring it off the road and...

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Newly identified pathway in mitochondria fuels tumor progression across...

Scientists at The Wistar Institute have identified a novel protein pathway across several types of cancer that controls how tumor cells acquire the energy necessary for movement, invasion and...

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Epigenetic change ties mitochondrial dysfunction to tumor progression

Mitochondria, the mighty energy factories of the cell, often malfunction in cancer, as well as in other conditions such as aging, neurodegenerative disease and heart disease. Whether these changes in...

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Research helps explain why androgen-deprivation therapy doesn't work for many...

Metastatic prostate cancer, or prostate cancer that has spread to other organs, is incurable. In new research published in the journal Science, Roswell Park Cancer Institute scientists have identified...

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Potentially reversible changes in gene control 'prime' pancreatic cancer...

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not...

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Anti-aging gene identified as a promising therapeutic target for older...

Scientists at The Wistar Institute have shown that an anti-diabetic drug can inhibit the growth of melanoma in older patients by activating an anti-aging gene that in turn inhibits a protein involved...

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Tighten the grip on metastasis

Metastasis is the major cause of cancer-related death and its appearance remains a phenomenon that is difficult to predict and manage. We now know that, prior to the arrival of the cancer cells,...

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Mass. General team identifies mechanisms behind resistance to FGFR inhibitor...

Investigators at the Massachusetts General Hospital (MGH) Cancer Center have identified the first genetic mechanisms conferring acquired resistance to a promising group of targeted cancer drugs. In a...

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Blood vessels and the immune system talk to each other; implications for...

Some cancer therapies aim at stopping tumor growth by affecting the blood vessels that nurture the tumor mass, while others act on the immune system attempting to eliminate the tumor. Researchers at...

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Biomarker could lead to personalized therapies for prostate cancer

In 2016, more than 181,000 new cases of prostate cancer were reported in the U.S., according to the American Cancer Society. The prostate-specific antigen (PSA) test is one of the earliest ways...

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Are men with a family history of prostate cancer eligible for active...

Active surveillance—careful monitoring to determine if or when a cancer warrants treatment—is an increasingly prevalent choice for prostate cancer, but it's unclear if the strategy is appropriate for...

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Study identifies new target to fight prostate, lung cancer

A newly identified molecular chain of events in a mouse model of prostate cancer highlights novel targets to treat it and other cancers. A team led by Marcelo Kazanietz, PhD, a professor of Systems...

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Cancer drug design targeted by COSMIC's new 3-D system

COSMIC-3D, the most comprehensive system for exploring cancer mutations in three dimensions, is launched today by COSMIC, based at the Wellcome Trust Sanger Institute, in collaboration with Astex...

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New clinical trial framework tests 'natural' cures for cancer

A University of Colorado Cancer Center clinical trial is now recruiting prostate cancer patients who would otherwise be on a watch-and-wait protocol to test the ability of grape seed extract to slow...

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Scientists focus on 'guardian of the genome' to understand preterm births

Scientists have gotten a better look at the effects of a gene known as the "guardian of the genome" in causing premature births and miscarriages.

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Drug helps fight breast tumors tied to 'cancer genes'

A twice-daily pill could help some advanced breast cancer patients avoid or delay follow-up sessions of chemotherapy, a new clinical trial reports.

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First-line immunotherapy treatment can improve survival for subset of lung...

Findings from a phase III clinical trial for advanced lung cancer patients could help oncologists better predict which patients are likely to receive the most benefit from immunotherapy as a first-line...

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Researchers gain insights into the growth of liver cancer tumors and their...

Liver cancer tumors are genetically diverse and therefore difficult to treat, a Singaporean research team reports. The genetic differences found in each patient may one day enable personal, targeted...

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Chemo plus hyperthermia active in advanced pancreatic cancer

(HealthDay)—For patients with locally advanced or metastatic pancreatic carcinoma with malignant ascites, a combined systemic and intraperitoneal chemotherapy approach plus hyperthermia is well...

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How a chemo drug can help cancer spread from the breast to the lungs

COLUMBUS, Ohio -The very same treatment that thwarts breast cancer has a dark side—it can fuel the spread of the disease to the lungs.

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New insights on the addictions of tumors

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) and UC San Diego have shown that tumors can ensure a more reliable nutrient supply by eliminating the p62 protein in surrounding...

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Researchers identify a potential molecular trigger for invasiveness in...

A small protein modification can trigger the aggressive migratory and invasive properties of prostate cancer cells, according to new research published on the cover of Oncotarget. The findings give...

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Memo to doctors: spit out the bad news

(HealthDay)—Doctors, don't be afraid to deliver bad news.

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Study reveals cancer therapy's double-edged sword... and how to blunt it

Researchers from Harvard Medical School and the Institute of Systems Biology have discovered that the remains of tumor cells killed by chemotherapy or other cancer treatments can actually stimulate...

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Communication between lung tumors and bones contributes to tumor progression

Massachusetts General Hospital (MGH) investigators have identified a way in which a type of lung cancer co-opts a portion of the immune system to increase tumor progression. In the Dec. 1 issue of...

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Scientists shed light on a tumor-suppressive protein in metastases

A new study conducted at the VIB-KU Leuven Center for Cancer Biology in Belgium has labeled the protein Caveolin-1 as a high-potential target in the fight against cancer. Many research projects have...

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Drug suppresses spread of breast cancer caused by stem-like cells

Rare stem-like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before...

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The immune cells that help tumors instead of destroying them

Lung cancer is the leading cause of cancer-associated deaths. One of the most promising ways to treat it is by immunotherapy, a strategy that turns the patient's immune system against the tumor. In the...

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Cancer's gene-determined 'immune landscape' dictates progression of prostate...

The field of immunotherapy - the harnessing of patients' own immune systems to fend off cancer - is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in...

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Dietary fat, changes in fat metabolism may promote prostate cancer metastasis

Prostate tumors tend to be what scientists call "indolent" - so slow-growing and self-contained that many affected men die with prostate cancer, not of it. But for the percentage of men whose prostate...

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